Endocrine Abstracts

Case: A 21 year old gentleman presented to endocrine clinic with failure to develop secondary sexual characteristics. He had no growth since age 16, nor any change in voice, body hair or muscle or genital growth. Examination was in keeping with pubertal staging Tanner stage II. His right testicular volume was 5ml and left testicular volume 4ml. He had normal sense of smell. Investigations demonstrated low testosterone at 1.6 nmol/l (10-30). Results showed hypogonadotropic hypo...

A 19 year old male was referred urgently due to a significantly raised Prolactin. He had seen his GP due to a cough, who then noted the patient had not progressed through puberty and organized further testing. On examination he had a BMI of 47. His height was 178 cm with a target of 184.5 cm (range 176-193). He had bilateral gynaecomastia with micropenis and pre-pubertal testes. He had never shaved and his voice was high-pitched. He did not report anosmia. Visual fields were n...

Background: Euthyroid hyperthyroxinaemia can present a diagnostic challenge. Abnormalities in the binding proteins of thyroid hormones can cause this discordant picture of thyroid function tests, with thyroxine binding globulin being the protein most commonly affected. Familial dysalbuminaemic hyperthyroxinaemia is a rarer cause, and is an autosomal dominant condition which can present with euthyroid hyperthyroxinaemia. This condition is associated with a mutation in albumin w...

Background: Iodine deficiency is a well known cause of goitre and abnormal thyroid function but is rare in patients born in the UK. Iodine is primarily found in fish and dairy products and patients who avoid these foods may be at risk of iodine deficiency.Case: A 22 year old gentleman was referred to endocrine clinic with an unusual pattern of thyroid function tests (TFTs). He had a goitre on examination. He had a background of irritable bowel syndrome a...

Introduction: Due to improved cancer survival rates, a rising number of CNS cancer survivors face late effects of therapy, such as hormone deficiencies. During adolesecence and young adulthood, specialised transition services are needed to cater for young peoples complex health needs and general needs, such as achieving independence. This study therefore audited a Teenage & Young Adult (TYA) neuro-oncology late effects clinic to identify areas of good practice and areas fo...

Background: Training is adolescent health and transition is lacking in medical education. Clinicians working in diabetes and endocrinology across paediatric and adult services need to have the skills to work effectively with this age group. Our aim was to identify the current state of training and to ascertain training needs in trainees.Methods: A questionnaire was developed based on existing questionnaires. Using trainee representatives all paediatric a...

Background: Transition is an important stage in the care of a young person with a long term endocrine condition.Objective: To explore current services for young people (YP) with endocrine conditions from the perspective of paediatric and adult endocrinologists, and YP and their parents using their services.Methods: There were two components: i) service questionnaire for completion by paediatric and adult endocrinologists. ii) &#145...